![]() Among all reported cases, osteosarcoma, Ewing sarcoma, and chondrosarcoma are the three most common primary bone cancer types, and breast, prostate, thyroid, and lung are the four regions of cancer origin with the highest bone metastasis risk. More than 220,000 patients die following treatment each year, resulting in a global survival rate of around 68%. Due to the low incidence of bone cancer, its delayed diagnosis and treatment are common, leading to high mortality. ![]() Around 700,000 new primary bone cancer cases are reported each year worldwide. Bone cancer is caused by cancer cells originating in bone tissue (primary bone cancer) or metastasized from other primary tumor areas to bone tissue (metastatic bone cancer). The total annual cancer-related economic costs in the USA added up to $183 billion for 2015, and €199 billion in Europe for 2018. According to the World Health Organization (WHO), cancer caused 10 million deaths in 2020 with 19.3 million new cases detected in the same year.
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